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https://hdl.handle.net/2440/69643
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Type: | Journal article |
Title: | Uptake and distribution of a platinum(II)-carborane complex within a tumour cell using synchrotron XRF imaging |
Author: | Crossley, E. Aitken, J. Vogt, S. Harris, H. Rendina, L. |
Citation: | Australian Journal of Chemistry: an international journal for chemical science, 2011; 64(3):253-257 |
Publisher: | C S I R O Publishing |
Issue Date: | 2011 |
ISSN: | 0004-9425 1445-0038 |
Statement of Responsibility: | Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina |
Abstract: | Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex containing a PtII-terpy (terpy = 2,2′:6′,2′′-terpyridine) unit linked to a functionalized closo-carborane cage results in the uptake of the complex within the cells, as determined by synchrotron X-ray fluorescence (XRF) imaging. Although a significant cellular uptake of Pt existed, there was no significant accumulation of the element within the cell nuclei. Other statistically significant changes from the XRF data included an increase in Cl, K, and Cu and a decrease in Fe within the treated cells. |
Rights: | Copyright CSIRO 2011 |
DOI: | 10.1071/CH10453 |
Grant ID: | http://purl.org/au-research/grants/arc/DP0557118 http://purl.org/au-research/grants/arc/DP0664706 http://purl.org/au-research/grants/arc/DP0557118 http://purl.org/au-research/grants/arc/DP0664706 |
Published version: | http://dx.doi.org/10.1071/ch10453 |
Appears in Collections: | Aurora harvest 5 Chemistry publications Environment Institute publications |
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