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https://hdl.handle.net/2440/69643
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DC Field | Value | Language |
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dc.contributor.author | Crossley, E. | - |
dc.contributor.author | Aitken, J. | - |
dc.contributor.author | Vogt, S. | - |
dc.contributor.author | Harris, H. | - |
dc.contributor.author | Rendina, L. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Australian Journal of Chemistry: an international journal for chemical science, 2011; 64(3):253-257 | - |
dc.identifier.issn | 0004-9425 | - |
dc.identifier.issn | 1445-0038 | - |
dc.identifier.uri | http://hdl.handle.net/2440/69643 | - |
dc.description.abstract | Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex containing a PtII-terpy (terpy = 2,2′:6′,2′′-terpyridine) unit linked to a functionalized closo-carborane cage results in the uptake of the complex within the cells, as determined by synchrotron X-ray fluorescence (XRF) imaging. Although a significant cellular uptake of Pt existed, there was no significant accumulation of the element within the cell nuclei. Other statistically significant changes from the XRF data included an increase in Cl, K, and Cu and a decrease in Fe within the treated cells. | - |
dc.description.statementofresponsibility | Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina | - |
dc.language.iso | en | - |
dc.publisher | C S I R O Publishing | - |
dc.rights | Copyright CSIRO 2011 | - |
dc.source.uri | http://dx.doi.org/10.1071/ch10453 | - |
dc.title | Uptake and distribution of a platinum(II)-carborane complex within a tumour cell using synchrotron XRF imaging | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1071/CH10453 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0557118 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0664706 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0557118 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0664706 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Harris, H. [0000-0002-3472-8628] | - |
Appears in Collections: | Aurora harvest 5 Chemistry publications Environment Institute publications |
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