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https://hdl.handle.net/2440/99739
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Type: | Journal article |
Title: | In utero Programming of Allergic Susceptibility |
Author: | Grieger, J. Clifton, V. Tuck, A. Wooldridge, A. Robertson, S. Gatford, K. |
Citation: | International Archives of Allergy and Applied Immunology, 2016; 169(2):80-92 |
Publisher: | Karger |
Issue Date: | 2016 |
ISSN: | 1018-2438 1423-0097 |
Statement of Responsibility: | Jessica A. Grieger, Vicki L. Clifton, Astrud R. Tuck, Amy L. Wooldridge, Sarah A. Robertson, Kathryn L. Gatford |
Abstract: | Background: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions. |
Keywords: | Placenta Animals Humans Prenatal Exposure Delayed Effects Hypersensitivity Disease Susceptibility Diet Risk Factors Maternal Exposure Immunity, Maternally-Acquired DNA Methylation Epigenesis, Genetic Pregnancy Dietary Supplements Infant, Newborn Female |
Rights: | © 2016 S. Karger AG, Basel |
DOI: | 10.1159/000443961 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1041918 |
Published version: | http://dx.doi.org/10.1159/000443961 |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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