Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9741
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men |
Author: | Feinle-Bisset, C. Chapman, I. Wishart, J. Horowitz, M. |
Citation: | Peptides, 2002; 23(8):1491-1495 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2002 |
ISSN: | 0196-9781 1873-5169 |
Statement of Responsibility: | Christine Feinle, Ian M. Chapman, Judith Wishart, Michael Horowitz |
Abstract: | It has been suggested that obesity is associated with a reduced glucagon-like peptide-1 (GLP-1) response to oral carbohydrate, but not fat. The latter may, however, be attributable to changes in gastric emptying. We have assessed plasma GLP-1 levels in response to these infusions in lean and obese subjects. Seven healthy lean (body mass index (BMI), 19.1-24.6 kg/m(2)) and seven obese (BMI, 31.3-40.8 kg/m(2)) young men received an intraduodenal infusion of glucose and fat for 120 min (2.86 kcal/min) on two separate days. Blood samples for plasma GLP-1 were obtained at baseline and every 20 min during the infusion. Plasma GLP-1 increased during infusion of glucose and fat (P = 0.001), but there were no differences between lean and obese subjects, nor the two nutrients. We conclude that GLP-1 secretion in response to duodenal infusion of glucose and fat is not altered in obese subjects. |
Keywords: | Glucagon-like peptide-1 Obesity Glucose Fat Duodenal infusion |
Description: | Copyright © 2002 Elsevier Science Inc. All rights reserved. |
DOI: | 10.1016/S0196-9781(02)00087-6 |
Published version: | http://dx.doi.org/10.1016/s0196-9781(02)00087-6 |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.