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dc.contributor.authorFeinle-Bisset, C.en
dc.contributor.authorChapman, I.en
dc.contributor.authorWishart, J.en
dc.contributor.authorHorowitz, M.en
dc.identifier.citationPeptides, 2002; 23(8):1491-1495en
dc.descriptionCopyright © 2002 Elsevier Science Inc. All rights reserved.en
dc.description.abstractIt has been suggested that obesity is associated with a reduced glucagon-like peptide-1 (GLP-1) response to oral carbohydrate, but not fat. The latter may, however, be attributable to changes in gastric emptying. We have assessed plasma GLP-1 levels in response to these infusions in lean and obese subjects. Seven healthy lean (body mass index (BMI), 19.1-24.6 kg/m(2)) and seven obese (BMI, 31.3-40.8 kg/m(2)) young men received an intraduodenal infusion of glucose and fat for 120 min (2.86 kcal/min) on two separate days. Blood samples for plasma GLP-1 were obtained at baseline and every 20 min during the infusion. Plasma GLP-1 increased during infusion of glucose and fat (P = 0.001), but there were no differences between lean and obese subjects, nor the two nutrients. We conclude that GLP-1 secretion in response to duodenal infusion of glucose and fat is not altered in obese subjects.en
dc.description.statementofresponsibilityChristine Feinle, Ian M. Chapman, Judith Wishart, Michael Horowitzen
dc.publisherElsevier Science Incen
dc.subjectGlucagon-like peptide-1; Obesity; Glucose; Fat; Duodenal infusionen
dc.titlePlasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese menen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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