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|Title:||Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men|
|Citation:||Peptides, 2002; 23(8):1491-1495|
|Publisher:||Elsevier Science Inc|
|Christine Feinle, Ian M. Chapman, Judith Wishart, Michael Horowitz|
|Abstract:||It has been suggested that obesity is associated with a reduced glucagon-like peptide-1 (GLP-1) response to oral carbohydrate, but not fat. The latter may, however, be attributable to changes in gastric emptying. We have assessed plasma GLP-1 levels in response to these infusions in lean and obese subjects. Seven healthy lean (body mass index (BMI), 19.1-24.6 kg/m(2)) and seven obese (BMI, 31.3-40.8 kg/m(2)) young men received an intraduodenal infusion of glucose and fat for 120 min (2.86 kcal/min) on two separate days. Blood samples for plasma GLP-1 were obtained at baseline and every 20 min during the infusion. Plasma GLP-1 increased during infusion of glucose and fat (P = 0.001), but there were no differences between lean and obese subjects, nor the two nutrients. We conclude that GLP-1 secretion in response to duodenal infusion of glucose and fat is not altered in obese subjects.|
|Keywords:||Glucagon-like peptide-1; Obesity; Glucose; Fat; Duodenal infusion|
|Description:||Copyright © 2002 Elsevier Science Inc. All rights reserved.|
|Appears in Collections:||Medicine publications|
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