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Type: Journal article
Title: High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men
Author: Boyd, K.
O'Donovan, D.
Doran, S.
Wishart, J.
Chapman, I.
Horowitz, M.
Feinle-Bisset, C.
Citation: American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003; 284(2):G188-G196
Publisher: Amer Physiological Soc
Issue Date: 2003
ISSN: 0193-1857
Statement of
K. A. Boyd, D. G. O'Donovan, S. Doran, J. Wishart, I. M. Chapman, M. Horowitz, and C. Feinle
Abstract: There is evidence that gastrointestinal function adapts in response to a highfat (HF) diet. This study investigated the hypothesis that an HF diet modifies the acute effects of duodenal lipid on appetite, antropyloroduodenal pressures, plasma CCK and plasma glucagon-like peptide-1 (GLP-1) levels in humans. Twelve healthy men were studied twice in randomized, crossover fashion. The effects of a 90-min duodenal lipid infusion (6.3 kJ/min) on the above parameters were assessed immediately following 14-day periods on either an HF or a low-fat (LF) diet. After the HF diet, pyloric tonic and phasic pressures were attenuated, and the number of antropyloroduodenal pressure-wave sequences was increased when compared with the LF diet. Plasma CCK and GLP-1 levels did not differ between the two diets. Hunger was greater during the lipid infusion following the HF diet, but there was no difference in food intake. Therefore, exposure to an HF diet for 14 days attenuates the effects of duodenal lipid on antropyloroduodenal pressures and hunger without affecting food intake or plasma hormone levels.
Keywords: antropyloroduodenal pressures; cholecystokinin; glucose-like peptide-1; energy intake
Description: Published abstract used with permission of the copyright owner.
Rights: © 2003 American Physiological Society
RMID: 0020030364
DOI: 10.1152/ajpgi.00375.2002
Appears in Collections:Medicine publications

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