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https://hdl.handle.net/2440/89669
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Type: | Journal article |
Title: | Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide? |
Author: | Wu, T. Trahair, L. Bound, M. Deacon, C. Horowitz, M. Rayner, C. Jones, K. |
Citation: | Diabetic Medicine, 2015; 32(5):595-600 |
Publisher: | Wiley |
Issue Date: | 2015 |
ISSN: | 0742-3071 1464-5491 |
Statement of Responsibility: | T. Wu, L. G. Trahair, M. J. Bound, C. F. Deacon, M. Horowitz, C. K. Rayner, and K. L. Jones |
Abstract: | AIMS: To evaluate the effects of the dipeptidyl peptidase-4 inhibitor sitagliptin on blood pressure and heart rate, measured during a previously reported study, in which the effects of sitagliptin during intraduodenal glucose infusion at the rate of 2 kcal/min on glucose homeostasis were examined in patients with Type 2 diabetes. METHODS: A total of 10 people with Type 2 diabetes were studied on two different days, 30 min after oral ingestion of sitagliptin (100 mg) or placebo. Intraduodenal glucose was infused at 2 kcal/min (60 g over 120 min), and blood pressure, heart rate, plasma glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (total and intact), glucose, insulin and glucagon responses were evaluated. RESULTS: In response to intraduodenal glucose infusion, heart rate (treatment effect: P = 0.001) and serum insulin concentration (treatment × time interaction: P = 0.041) were higher after sitagliptin treatment than placebo, without a significant difference in blood pressure, plasma glucagon or glucose. During intraduodenal glucose infusion, there was a substantial increase in plasma total glucose-dependent insulinotropic polypeptide on both days (time effect: P < 0.001), but not in total glucagon-like peptide-1. After sitagliptin, plasma intact glucagon-like peptide-1 concentration increased slightly (treatment × time interaction: P = 0.044) and glucose-dependent insulinotropic polypeptide concentration increased substantially (treatment × time interaction: P = 0.003).The heart rate response to intraduodenal glucose was related directly to plasma intact glucose-dependent insulinotropic polypeptide concentrations (r = 0.75, P = 0.008). CONCLUSIONS: Sitagliptin increased the heart rate response to intraduodenal glucose infusion at 2 kcal/min in people with Type 2 diabetes, which was associated with augmentation of plasma intact glucose-dependent insulinotropic polypeptide concentrations. These observations warrant further clarification of a potential role for glucose-dependent insulinotropic polypeptide in the control of the 'gut-heart' axis. |
Keywords: | Duodenum Humans Diabetes Mellitus, Type 2 Gastric Inhibitory Polypeptide Glucose Hypoglycemic Agents Administration, Oral Retrospective Studies Double-Blind Method Homeostasis Blood Pressure Heart Rate Time Factors Aged Male Dipeptidyl-Peptidase IV Inhibitors Sitagliptin Phosphate |
Description: | Short report: treatment |
Rights: | © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK |
DOI: | 10.1111/dme.12622 |
Published version: | http://dx.doi.org/10.1111/dme.12622 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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