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https://hdl.handle.net/2440/89669
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dc.contributor.author | Wu, T. | - |
dc.contributor.author | Trahair, L. | - |
dc.contributor.author | Bound, M. | - |
dc.contributor.author | Deacon, C. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Jones, K. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Diabetic Medicine, 2015; 32(5):595-600 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.issn | 1464-5491 | - |
dc.identifier.uri | http://hdl.handle.net/2440/89669 | - |
dc.description | Short report: treatment | - |
dc.description.abstract | AIMS: To evaluate the effects of the dipeptidyl peptidase-4 inhibitor sitagliptin on blood pressure and heart rate, measured during a previously reported study, in which the effects of sitagliptin during intraduodenal glucose infusion at the rate of 2 kcal/min on glucose homeostasis were examined in patients with Type 2 diabetes. METHODS: A total of 10 people with Type 2 diabetes were studied on two different days, 30 min after oral ingestion of sitagliptin (100 mg) or placebo. Intraduodenal glucose was infused at 2 kcal/min (60 g over 120 min), and blood pressure, heart rate, plasma glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (total and intact), glucose, insulin and glucagon responses were evaluated. RESULTS: In response to intraduodenal glucose infusion, heart rate (treatment effect: P = 0.001) and serum insulin concentration (treatment × time interaction: P = 0.041) were higher after sitagliptin treatment than placebo, without a significant difference in blood pressure, plasma glucagon or glucose. During intraduodenal glucose infusion, there was a substantial increase in plasma total glucose-dependent insulinotropic polypeptide on both days (time effect: P < 0.001), but not in total glucagon-like peptide-1. After sitagliptin, plasma intact glucagon-like peptide-1 concentration increased slightly (treatment × time interaction: P = 0.044) and glucose-dependent insulinotropic polypeptide concentration increased substantially (treatment × time interaction: P = 0.003).The heart rate response to intraduodenal glucose was related directly to plasma intact glucose-dependent insulinotropic polypeptide concentrations (r = 0.75, P = 0.008). CONCLUSIONS: Sitagliptin increased the heart rate response to intraduodenal glucose infusion at 2 kcal/min in people with Type 2 diabetes, which was associated with augmentation of plasma intact glucose-dependent insulinotropic polypeptide concentrations. These observations warrant further clarification of a potential role for glucose-dependent insulinotropic polypeptide in the control of the 'gut-heart' axis. | - |
dc.description.statementofresponsibility | T. Wu, L. G. Trahair, M. J. Bound, C. F. Deacon, M. Horowitz, C. K. Rayner, and K. L. Jones | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK | - |
dc.source.uri | http://dx.doi.org/10.1111/dme.12622 | - |
dc.subject | Duodenum | - |
dc.subject | Humans | - |
dc.subject | Diabetes Mellitus, Type 2 | - |
dc.subject | Gastric Inhibitory Polypeptide | - |
dc.subject | Glucose | - |
dc.subject | Hypoglycemic Agents | - |
dc.subject | Administration, Oral | - |
dc.subject | Retrospective Studies | - |
dc.subject | Double-Blind Method | - |
dc.subject | Homeostasis | - |
dc.subject | Blood Pressure | - |
dc.subject | Heart Rate | - |
dc.subject | Time Factors | - |
dc.subject | Aged | - |
dc.subject | Male | - |
dc.subject | Dipeptidyl-Peptidase IV Inhibitors | - |
dc.subject | Sitagliptin Phosphate | - |
dc.title | Effects of sitagliptin on blood pressure and heart rate in response to intraduodenal glucose infusion in patients with Type 2 diabetes: a potential role for glucose-dependent insulinotropic polypeptide? | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/dme.12622 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wu, T. [0000-0003-1656-9210] | - |
dc.identifier.orcid | Bound, M. [0000-0003-0211-5832] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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