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https://hdl.handle.net/2440/8501
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Type: | Journal article |
Title: | Placental vascular development and neonatal outcome |
Author: | Khong, T. |
Citation: | Seminars in Fetal and Neonatal Medicine, 2004; 9(4):255-263 |
Publisher: | Elsevier Ltd. |
Issue Date: | 2004 |
ISSN: | 1744-165X 1084-2756 |
Abstract: | The juxtaposition of the maternal and fetal circulations allows optimal physiological exchange between mother and fetus. Extravillous trophoblast infiltrating into the placental bed transforms the small calibre spiral arteries into large calibre uteroplacental arteries. The absence of these physiological changes, coupled with other lesions such as acute atherosis, results in a reduced uteroplacental blood flow, as seen in pre-eclampsia, intrauterine growth restriction and preterm delivery. A failure to elaborate the placental vascular tree can result in impaired flow through the fetal placental circulation. Placental vascular malformations, such as placental mesenchymal dysplasia and the commoner chorangioma, can lead to neonatal complications. Fetal thrombotic vasculopathy, commonly associated with thrombophilia, may be a cause of neurological deficit in childhood. |
Keywords: | Placenta Humans Placenta Diseases Pregnancy Outcome Embryonic and Fetal Development Pregnancy Maternal-Fetal Exchange Placentation Neovascularization, Physiologic Infant, Newborn Female |
DOI: | 10.1016/j.siny.2003.11.010 |
Published version: | http://dx.doi.org/10.1016/j.siny.2003.11.010 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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