Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8154
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Alcohol consumption and insulin resistance in young adults |
Author: | Flanagan, D. Moore, V. Godsland, I. Cockington, R. Robinson, J. Phillips, D. |
Citation: | European Journal of Clinical Investigation, 2000; 30(4):297-301 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2000 |
ISSN: | 0014-2972 1365-2362 |
Abstract: | <h4>Background</h4>Alcohol may have a cardioprotective effect. One possible mechanism is by reducing insulin resistance, a known cardiovascular risk factor. The aim of this study was to assess the relationship between alcohol consumption, insulin resistance and other parameters determining glucose tolerance in 154 young men and women.<h4>Subjects and methods</h4>Subjects completed a questionnaire documenting weekly alcohol consumption. Insulin sensitivity and glucose tolerance were measured using the intravenous glucose tolerance test with minimal model analysis. Height, weight, usual level of exercise, smoking habits and socio-economic status were also recorded.<h4>Results</h4>Insulin sensitivity correlated inversely with body mass index (r = - 0.529, P < 0.001) but not with level of physical fitness. Women were significantly less insulin sensitive than men (4.19 and 5.63 104 min-1 pmol-1 L-1, respectively; P < 0.001). Insulin sensitivity correlated positively with alcohol consumption and this trend remained significant allowing for body mass index and gender (beta = 0.17, P < 0.014). First-phase insulin secretion showed a weak but non-significant trend in the opposite direction. Fasting glucose, fasting insulin and glucose tolerance showed no relationships with alcohol consumption.<h4>Conclusion</h4>These data suggest a close relationship between alcohol consumption and insulin resistance in young adults. Regular alcohol consumption is associated with decreased insulin resistance and this may partly explain the cardioprotective effect of alcohol. |
Keywords: | Humans Insulin Resistance Insulin Blood Glucose Glucose Tolerance Test Body Mass Index Confidence Intervals Cohort Studies Alcohol Drinking Sex Characteristics Physical Fitness Adult Female Male Surveys and Questionnaires |
DOI: | 10.1046/j.1365-2362.2000.00624.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2362.2000.00624.x |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.