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Type: Journal article
Title: Glucagon-like peptides 1 and 2 in health and disease: A review
Author: Marathe, C.
Rayner, C.
Jones, K.
Horowitz, M.
Citation: Peptides, 2013; 44:75-86
Publisher: Elsevier Science Inc
Issue Date: 2013
ISSN: 0196-9781
Statement of
Chinmay S. Marathe, Christopher K. Rayner, Karen L. Jones, Michael Horowitz
Abstract: The gut derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), are secreted following nutrient ingestion. GLP-1 and another gut peptide, glucose-dependent insulinotropic polypeptide (GIP) are collectively referred to as 'incretin' hormones, and play an important role in glucose homeostasis. Incretin secretion shares a complex interdependent relationship with both postprandial glycemia and the rate of gastric emptying. GLP-1 based therapies are now well established in the management of type 2 diabetes, while recent literature has suggested potential applications to treat obesity and protect against cardiovascular and neurological disease. The mechanism of action of GLP-2 is not well understood, but it shows promise as an intestinotropic agent.
Keywords: Pancreas; Animals; Humans; Diabetes Mellitus, Type 2; Blood Glucose; Receptors, Glucagon; Gastric Emptying; Postprandial Period; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Clinical Trials as Topic; Incretins
Rights: © 2013 Elsevier Inc. All rights reserved.
RMID: 0020130307
DOI: 10.1016/j.peptides.2013.01.014
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Appears in Collections:Medicine publications

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