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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/80360
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dc.contributor.authorMarathe, C.-
dc.contributor.authorRayner, C.-
dc.contributor.authorJones, K.-
dc.contributor.authorHorowitz, M.-
dc.date.issued2013-
dc.identifier.citationPeptides, 2013; 44:75-86-
dc.identifier.issn0196-9781-
dc.identifier.issn1873-5169-
dc.identifier.urihttp://hdl.handle.net/2440/80360-
dc.description.abstractThe gut derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GLP-2), are secreted following nutrient ingestion. GLP-1 and another gut peptide, glucose-dependent insulinotropic polypeptide (GIP) are collectively referred to as 'incretin' hormones, and play an important role in glucose homeostasis. Incretin secretion shares a complex interdependent relationship with both postprandial glycemia and the rate of gastric emptying. GLP-1 based therapies are now well established in the management of type 2 diabetes, while recent literature has suggested potential applications to treat obesity and protect against cardiovascular and neurological disease. The mechanism of action of GLP-2 is not well understood, but it shows promise as an intestinotropic agent.-
dc.description.statementofresponsibilityChinmay S. Marathe, Christopher K. Rayner, Karen L. Jones, Michael Horowitz-
dc.language.isoen-
dc.publisherElsevier Science Inc-
dc.rights© 2013 Elsevier Inc. All rights reserved.-
dc.source.urihttp://www.sciencedirect.com/science/article/pii/S0196978113000338-
dc.subjectPancreas-
dc.subjectAnimals-
dc.subjectHumans-
dc.subjectDiabetes Mellitus, Type 2-
dc.subjectBlood Glucose-
dc.subjectReceptors, Glucagon-
dc.subjectGastric Emptying-
dc.subjectPostprandial Period-
dc.subjectGlucagon-Like Peptide 1-
dc.subjectGlucagon-Like Peptide 2-
dc.subjectClinical Trials as Topic-
dc.subjectIncretins-
dc.titleGlucagon-like peptides 1 and 2 in health and disease: A review-
dc.typeJournal article-
dc.identifier.doi10.1016/j.peptides.2013.01.014-
pubs.publication-statusPublished-
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]-
dc.identifier.orcidJones, K. [0000-0002-1155-5816]-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
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