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Type: Journal article
Title: Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans
Author: Wu, T.
Bound, M.
Standfield, S.
Gedulin, B.
Jones, K.
Horowitz, M.
Rayner, C.
Citation: Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 2013; 15(5):474-477
Publisher: Blackwell Publishing Ltd
Issue Date: 2013
ISSN: 1462-8902
Statement of
T. Wu, M. J. Bound, S. D. Standfield, B.Gedulin, K. L. Jones, M. Horowitz & C. K. Rayner
Abstract: Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation. We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.
Keywords: bile salt
glucagon-like peptide 1
peptide YY
Rights: © 2012 Blackwell Publishing Ltd
DOI: 10.1111/dom.12043
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