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https://hdl.handle.net/2440/79742
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dc.contributor.author | Wu, T. | - |
dc.contributor.author | Bound, M. | - |
dc.contributor.author | Standfield, S. | - |
dc.contributor.author | Gedulin, B. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 2013; 15(5):474-477 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.issn | 1463-1326 | - |
dc.identifier.uri | http://hdl.handle.net/2440/79742 | - |
dc.description.abstract | Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation. We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner. These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity. | - |
dc.description.statementofresponsibility | T. Wu, M. J. Bound, S. D. Standfield, B.Gedulin, K. L. Jones, M. Horowitz & C. K. Rayner | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.rights | © 2012 Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/dom.12043 | - |
dc.subject | bile salt | - |
dc.subject | glucagon-like peptide 1 | - |
dc.subject | peptide YY | - |
dc.title | Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/dom.12043 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wu, T. [0000-0003-1656-9210] | - |
dc.identifier.orcid | Bound, M. [0000-0003-0211-5832] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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