Adelaide Research & Scholarship
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https://hdl.handle.net/2440/77002
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| Type: | Journal article |
| Title: | Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres |
| Author: | Popat, A. Ross, B. Liu, J. Jambhrunkar, S. Kleitz, F. Qiao, S. |
| Citation: | Angewandte Chemie International Edition, 2012; 51(50):12486-12489 |
| Publisher: | Wiley-V C H Verlag GMBH |
| Issue Date: | 2012 |
| ISSN: | 1433-7851 1521-3773 |
| Statement of Responsibility: | Amirali Popat, Benjamin P. Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, and Shi Zhang Qiao |
| Abstract: | I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released. |
| Keywords: | azo-reductase colon targeting drug delivery nanoparticles sulfasalazine |
| Rights: | Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| DOI: | 10.1002/anie.201206416 |
| Grant ID: | http://purl.org/au-research/grants/arc/LP0882681 |
| Published version: | http://dx.doi.org/10.1002/anie.201206416 |
| Appears in Collections: | Aurora harvest Chemical Engineering publications |
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