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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/77002
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dc.contributor.authorPopat, A.-
dc.contributor.authorRoss, B.-
dc.contributor.authorLiu, J.-
dc.contributor.authorJambhrunkar, S.-
dc.contributor.authorKleitz, F.-
dc.contributor.authorQiao, S.-
dc.date.issued2012-
dc.identifier.citationAngewandte Chemie International Edition, 2012; 51(50):12486-12489-
dc.identifier.issn1433-7851-
dc.identifier.issn1521-3773-
dc.identifier.urihttp://hdl.handle.net/2440/77002-
dc.description.abstractI want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.-
dc.description.statementofresponsibilityAmirali Popat, Benjamin P. Ross, Jian Liu, Siddharth Jambhrunkar, Freddy Kleitz, and Shi Zhang Qiao-
dc.language.isoen-
dc.publisherWiley-V C H Verlag GMBH-
dc.rightsCopyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.source.urihttp://dx.doi.org/10.1002/anie.201206416-
dc.subjectazo-reductase-
dc.subjectcolon targeting-
dc.subjectdrug delivery-
dc.subjectnanoparticles-
dc.subjectsulfasalazine-
dc.titleEnzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres-
dc.typeJournal article-
dc.identifier.doi10.1002/anie.201206416-
dc.relation.granthttp://purl.org/au-research/grants/arc/LP0882681-
pubs.publication-statusPublished-
dc.identifier.orcidQiao, S. [0000-0002-1220-1761] [0000-0002-4568-8422]-
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Chemical Engineering publications

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