Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7511
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Type: | Journal article |
Title: | Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children |
Author: | Belshe, R. Newman, F. Anderson, E. Wright, P. Karron, R. Tollefson, S. Henderson, F. Meissner, H. Madhi, S. Roberton, D. Marshall, H. Loh, R. Sly, P. Murphy, B. Tatem, J. Randolph, V. Hackell, J. Gruber, W. Tsai, T. |
Citation: | Journal of Infectious Diseases, 2004; 190(12):2096-2103 |
Publisher: | Univ Chicago Press |
Issue Date: | 2004 |
ISSN: | 0022-1899 1537-6613 |
Statement of Responsibility: | Robert B. Belshe, Frances K. Newman, Edwin L. Anderson, Peter F. Wright, Ruth A. Karron,Sharon Tollefson, Frederick W. Henderson, H. Cody Meissner, Shabir Madhi, Don Roberton, Helen Marshall,Richard Loh, Peter Sly, Brian Murphy, Joanne M. Tatem, Valerie Randolph, Jill Hackell, William Gruber and Theodore F. Tsai |
Abstract: | We evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6–18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 105 plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3-cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/PV3 vaccine is feasible for simultaneous administration, and further studies are warranted. |
Keywords: | Humans Parainfluenza Virus 3, Human Respirovirus Infections Respiratory Syncytial Virus Infections Vaccines, Combined Parainfluenza Vaccines Respiratory Syncytial Virus Vaccines Antibodies, Viral Administration, Intranasal Double-Blind Method Virus Shedding Infant |
Description: | © 2004 by the Infectious Diseases Society of America. All rights reserved. |
DOI: | 10.1086/425981 |
Published version: | http://dx.doi.org/10.1086/425981 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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hdl_7511.pdf | 159.91 kB | Publisher's PDF | View/Open |
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