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https://hdl.handle.net/2440/7182
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Type: | Journal article |
Title: | Dietary fats do not contribute to hyperlipidemia in children and adolescents with type 1 diabetes |
Author: | Wiltshire, E. Hirte, C. Couper, J. |
Citation: | Diabetes Care, 2003; 26(5):1356-1361 |
Publisher: | Amer Diabetes Assoc |
Issue Date: | 2003 |
ISSN: | 0149-5992 1935-5548 |
Statement of Responsibility: | Esko J. Wiltshire, Craig Hirte and Jennifer J. Couper |
Abstract: | <h4>Objective</h4>To determine the relative influence of diet, metabolic control, and familial factors on lipids in children with type 1 diabetes and control subjects.<h4>Research design and methods</h4>We assessed fasting serum cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, lipoprotein(a), apolipoprotein (apo)-A1, and apoB in 79 children and adolescents with type 1 diabetes and 61 age- and sex-matched control subjects, together with dietary intakes using a quantitative food frequency questionnaire.<h4>Results</h4>Total cholesterol, LDL cholesterol, apoB, HDL cholesterol, and apoA1 were significantly higher in children with diabetes. Children with diabetes had higher percentage energy intake from complex carbohydrates (P = 0.001) and fiber intake (P = 0.02), and they had lower intake of refined sugar (P < 0.001) and percentage energy from saturated fat (P = 0.045) than control subjects. Total cholesterol (beta = 0.43, P < 0.001), LDL cholesterol (beta = 0.4, P < 0.001), and apoB (beta = 0.32, P = 0.006) correlated independently with HbA(1c) but not dietary intake. HDL cholesterol (beta = 0.24, P = 0.05) and apoA1 (beta = 0.32, P = 0.004) correlated independently with HbA(1c), and HDL cholesterol (beta = -0.34, P = 0.009) correlated with percentage energy intake from complex carbohydrates. Triglycerides correlated independently with percentage energy intake from complex carbohydrates (beta = 0.33, P = 0.01) and insulin dose (beta = 0.26, P = 0.04). Subjects with diabetes and elevated LDL (>3.35 mmol/l, >130 mg/dl), for whom dietary therapy would be recommended, had significantly higher HbA(1c) (P = 0.007), but they had higher intake of complex carbohydrates than subjects with LDL cholesterol <3.35 mmol/l.<h4>Conclusions</h4>Lipid abnormalities remain common in children and adolescents with type 1 diabetes who adhere to current dietary recommendations, and they relate to metabolic control but not dietary intake. |
Keywords: | Humans Diabetes Mellitus, Type 1 Cholesterol Insulin Dietary Fats Triglycerides Lipoproteins Lipoprotein(a) Feeding Behavior Adolescent Child Female Male Hyperlipidemias Surveys and Questionnaires Glycated Hemoglobin |
Description: | Copyright © 2003 by the American Diabetes Association. |
DOI: | 10.2337/diacare.26.5.1356 |
Published version: | http://dx.doi.org/10.2337/diacare.26.5.1356 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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