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https://hdl.handle.net/2440/6945
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Type: | Journal article |
Title: | Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats |
Author: | Steeb, C.B. Shoubridge, C. Tivey, D. Read, L. |
Citation: | American Journal of Physiology, 1997; 272(3 Pt 1):G522-G533 |
Publisher: | AMER PHYSIOLOGICAL SOC |
Issue Date: | 1997 |
ISSN: | 0002-9513 2163-5773 |
Abstract: | This study describes developmental changes in gastrointestinal response to insulin-like growth factor I (IGF-I) peptide administration. Neonatal rats were infused with IGF-I or long [Arg3]IGF-I (LR(3)IGF-I) for 6.5 days starting on day 6 or 12 postpartum. Peptides were delivered by mini osmotic pumps at 0, 2, 5, or 12.5 microg x g(-1) x day(-1). IGF-I infusion increased plasma IGF-I levels in both age groups but stimulated body weight gain only in the older rats. Infusion of LR(3)IGF-I did not change plasma IGF-I levels. Both peptides enhanced expression of IGF-binding proteins (IGFBP) 1 and 2 and induced IGFBP-3 in the older rats. For both age groups, weights of the kidney and spleen increased by up to 85 and 76%, respectively. IGF-I treatment also stimulated gut weight and length by up to 60 and 32%, respectively, but dose dependency was observed only in the older rats. LR(3)IGF-I was more potent for all growth parameters in both age groups. Histological observations included thickening of the mucosa and muscularis externa after infusion of IGF-I peptides. Thymidine labeling in the younger rats indicated that proliferative activity increased proportionately with crypt cell growth. These results show that IGF-I peptides selectively stimulate growth of gastrointestinal tissues in suckling rats and that the proximal gut was the most peptide-responsive region. |
Keywords: | Intestines Intestinal Mucosa Duodenum Ileum Animals Animals, Suckling Rats Insulin Insulin-Like Growth Factor I Insulin-Like Growth Factor Binding Proteins Organ Size Age Factors Cell Division Molecular Weight |
DOI: | 10.1152/ajpgi.1997.272.3.G522 |
Published version: | http://dx.doi.org/10.1152/ajpgi.1997.272.3.g522 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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