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https://hdl.handle.net/2440/67367
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Type: | Journal article |
Title: | Discovery of lost diversity of paternal horse lineages using ancient DNA |
Author: | Lippold, S. Knapp, M. Kuznetsova, T. Leonard, J. Benecke, N. Ludwig, A. Rasmussen, M. Cooper, A. Weinstock, J. Willerslev, E. Shapiro, B. Hofreiter, M. |
Citation: | Nature Communications, 2011; 2(1):1-6 |
Publisher: | Nature Publishing Group |
Issue Date: | 2011 |
ISSN: | 2041-1723 2041-1723 |
Statement of Responsibility: | Sebastian Lippold, Michael Knapp, Tatyana Kuznetsova, Jennifer A. Leonard, Norbert Benecke, Arne Ludwig, Morten Rasmussen, Alan Cooper, Jaco Weinstock, Eske Willerslev, Beth Shapiro and Michael Hofreiter |
Abstract: | Modern domestic horses display abundant genetic diversity within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of the diversity in both the ancestral (pre-domestication) maternal and paternal lineages. As wild horses are practically extinct, ancient DNA studies offer the only means to assess this ancestral diversity. Here we show considerable ancestral diversity in ancient male horses by sequencing 4 kb of Y chromosomal DNA from eight ancient wild horses and one 2,800-year-old domesticated horse. Both ancient and modern domestic horses form a separate branch from the ancient wild horses, with the Przewalski horse at its base. Our methodology establishes the feasibility of re-sequencing long ancient nuclear DNA fragments and demonstrates the power of ancient Y chromosome DNA sequence data to provide insights into the evolutionary history of populations. |
Keywords: | Y Chromosome Animals Horses DNA, Mitochondrial Evolution, Molecular Phylogeny Molecular Sequence Data Female Male Genetic Variation |
Rights: | © 2011 Macmillan Publishers Limited. All rights reserved. |
DOI: | 10.1038/ncomms1447 |
Published version: | http://dx.doi.org/10.1038/ncomms1447 |
Appears in Collections: | Aurora harvest 5 Earth and Environmental Sciences publications Environment Institute Leaders publications |
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