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https://hdl.handle.net/2440/66608
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Type: | Journal article |
Title: | Linkage of regulators of TGF-β activity in the fetal ovary to polycystic ovary syndrome |
Other Titles: | Linkage of regulators of TGF-beta activity in the fetal ovary to polycystic ovary syndrome |
Author: | Hatzirodos, N. Bayne, R. Irving-Rodgers, H. Hummitzsch, K. Sabatier, L. Lee, S. Bonner, W. Gibson, M. Rainey, W. Carr, B. Mason, H. Reinhardt, D. Anderson, R. Rodgers, R. |
Citation: | The FASEB Journal, 2011; 25(7):2256-2265 |
Publisher: | Federation Amer Soc Exp Biol |
Issue Date: | 2011 |
ISSN: | 0892-6638 1530-6860 |
Abstract: | Although not often discussed, the ovaries of women with polycystic ovary syndrome (PCOS) show all the hallmarks of increased TGF-β activity, with increased amounts of fibrous tissue and collagen in the ovarian capsule or tunica albuginea and ovarian stroma. Recent studies suggest that PCOS could have fetal origins. Genetic studies of PCOS have also found linkage with a microsatellite located in intron 55 of the extracellular matrix protein fibrillin 3. Fibrillins regulate TGF-β bioactivity in tissues by binding latent TGF-β binding proteins. We therefore examined expression of fibrillins 1-3, latent TGF-β binding proteins 1-4, and TGF-β 1-3 in bovine and human fetal ovaries at different stages of gestation and in adult ovaries. We also immunolocalized fibrillins 1 and 3. The results indicate that TGF-β pathways operate during ovarian fetal development, but most important, we show fibrillin 3 is present in the stromal compartments of fetal ovaries and is highly expressed at a critical stage early in developing human and bovine fetal ovaries when stroma is expanding and follicles are forming. These changes in expression of fibrillin 3 in the fetal ovary could lead to a predisposition to develop PCOS in later life. |
Keywords: | Ovary Ovarian Follicle Animals Cattle Humans Polycystic Ovary Syndrome Microfilament Proteins Transforming Growth Factor beta Immunohistochemistry Reverse Transcriptase Polymerase Chain Reaction Gene Expression Regulation, Developmental Pregnancy Female Transforming Growth Factor beta1 Transforming Growth Factor beta2 Latent TGF-beta Binding Proteins Transforming Growth Factor beta3 Fibrillins |
Rights: | Copyright © 2011 by the Federation of American Societies for Experimental Biology |
DOI: | 10.1096/fj.11-181099 |
Published version: | http://dx.doi.org/10.1096/fj.11-181099 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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