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https://hdl.handle.net/2440/57272
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Type: | Journal article |
Title: | The genome sequence of Taurine cattle: a window to ruminant biology and evolution |
Author: | Bovine Genome Sequencing and Analysis Consortium, Elsik, C. Tellam, R. Worley, K. |
Citation: | Science, 2009; 324(5926):522-528 |
Publisher: | American Association for the Advancement of Science |
Issue Date: | 2009 |
ISSN: | 0036-8075 1095-9203 |
Contributor: | Adelson, David Louis |
Statement of Responsibility: | The Bovine Genome Sequencing and Analysis Consortium, Christine G. Elsik, Ross L. Tellam, Kim C. Worley |
Abstract: | To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production. |
Keywords: | Bovine Genome Sequencing and Analysis Consortium Animals Animals, Domestic Cattle Humans Proteins MicroRNAs Sequence Analysis, DNA Evolution, Molecular Species Specificity Alternative Splicing Synteny Genome Molecular Sequence Data Female Male Genetic Variation Biological Evolution |
Description: | David L. Adelson is a member of The Bovine Genome Sequencing and Analysis Consortium. |
Rights: | Copyright 2009 by the American Association for the Advancement of Science; all rights reserved. |
DOI: | 10.1126/science.1169588 |
Published version: | http://dx.doi.org/10.1126/science.1169588 |
Appears in Collections: | Aurora harvest 5 Environment Institute publications Molecular and Biomedical Science publications |
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