Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/46932
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Identification and sequence analysis of chicken Toll-like receptors
Author: Yilmaz, A.
Shen, S.
Adelson, D.
Xavier, S.
Zhu, J.
Citation: Immunogenetics, 2005; 56(10):743-753
Publisher: Springer
Issue Date: 2005
ISSN: 0093-7711
1432-1211
Statement of
Responsibility: 
Ahmet Yilmaz, Shixue Shen, David L. Adelson, Suresh Xavier and James J. Zhu
Abstract: Toll-like receptors (TLRs) play an important role in the recognition of microbial components. Only chicken TLR2 and -4 have been reported in the literature. The objectives of this study were to identify new chicken TLRs and to evaluate evolutionary significance of these receptors. Searching chicken genomic databases and DNA sequencing revealed five new TLRs, TLR1 (type 1 and 2), -3, -5, and -7. No chicken orthologues of mammalian TLR8, -9, or -10 were found. As in mammals, all chicken TLRs (chTLRs) share identical protein secondary structure that consists of several leucine-rich domains, a transmembrane domain, and Toll/Interleukin-1 receptor domain(s). Phylogenetic analyses indicate that the identified chTLR genes are the orthologues of TLRs in mammals. Analyses of the number of synonymous substitutions per synonymous site and nonsynonymous substitutions per nonsynonymous site indicate that the nucleotide sequences coding for the leucine-rich repeats of chicken TLR1 type 1 and type 2 were significantly under positive Darwinian selection. In contrast, the sequences of other TLRs were under purifying selection. These results support the hypothesis that one of the major evolutionary strategies of the innate immune system is to recognize a few highly conserved microbial components with several conserved TLRs. The results also indicate that the sequence changes in the ligand-binding domains of TLR1 in chickens provide adaptive advantages during evolution.
Keywords: Toll-like receptors
Chicken
Positive selection
Purifying selection
Comparative genomics
DOI: 10.1007/s00251-004-0740-8
Appears in Collections:Aurora harvest 6
Environment Institute publications
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.