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https://hdl.handle.net/2440/44608
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Type: | Journal article |
Title: | A novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine is immunogenic and induces immune memory when co-administered with DTPa-HBV-IPV and conjugate pneumococcal vaccines in infants |
Author: | Nolan, T. Lambert, S. Roberton, D. Marshall, H. Richmond, P. Streeton, C. Poolman, J. Boutriau, D. |
Citation: | Vaccine, 2007; 25(51):8487-8499 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2007 |
ISSN: | 0264-410X 1873-2518 |
Statement of Responsibility: | Terry Nolan, Stephen Lambert, Don Roberton, Helen Marshall, Peter Richmond, Catherine Streeton, Jan Poolman, Dominique Boutriau |
Abstract: | Immunogenicity and safety of a novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine (Hib-MenCY-TT) candidate was evaluated when co-administered with DTPa-HBV-IPV(Pediarix)+PCV7(Prevnar) at 2-4-6 months of age. Anti-PRP concentrations >or= 1.0 microg/mL were observed in 92.9-98.7%, rSBA-MenC/Y titres >or= 1:8 in >98%, rSBA-MenC/Y titres >or= 1:128 in >95.8 and >89.9% subjects. PRP and MenC responses were similar to respective controls (ActHIB and Menjugate) including for antibody persistence. Response to co-administered vaccines was not impaired. Polysaccharide challenge (PRP, PSC, PSY at 11-14 months of age) evidenced immune memory was induced for Hib, MenC/Y conjugate components. The safety profile of Hib-MenCY-TT was similar to controls. Hib-MenCY-TT administered according to the current US Hib vaccine schedule has the potential to induce protective antibodies against Hib and meningococcal-CY disease in infants and toddlers. |
Keywords: | Neisseria meningitidis serogroup C Neisseria meningitidis serogroup Y Vaccine |
Description: | Copyright © 2007 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.vaccine.2007.10.013 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/30521/description#description |
Published version: | http://dx.doi.org/10.1016/j.vaccine.2007.10.013 |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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