Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/40011
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Cell-surface proteoglycan expression by lymphocytes from peripheral blood and gingiva in health and periodontal disease |
Author: | Manakil, J. Sugerman, P. Li, H. Seymour, G. Bartold, P. |
Citation: | Journal of Dental Research, 2001; 80(8):1704-1710 |
Publisher: | Inter Amer Assoc Dental Research |
Issue Date: | 2001 |
ISSN: | 0022-0345 1544-0591 |
Statement of Responsibility: | J. F. Manakil, P. B. Sugerman, H. Li, G. J. Seymour and P. M. Bartold |
Abstract: | Cell-surface proteoglycans are involved in lymphocyte migration and activation. This study investigated the expression of syndecan-1, syndecan-4, and glypican in peripheral blood lymphocytes and by lymphocytes in variously inflamed periodontal tissues. Gingival specimens from healthy, gingivitis, or chronic periodontitis sites were stained by means of antibodies against B- and T-lymphocytes and also syndecan-1, syndecan-4, and glypican. Syndecan-1 expression by peripheral blood mononuclear cells (PBMC) from healthy, gingivitis, and chronic periodontitis subjects was assessed by flow cytometry. Syndecan-1 was expressed by B-cells/plasma cells but not T-cells in both gingivitis and chronic periodontitis lesions. Both B-cells/plasma cells and T-cells in gingivitis and chronic periodontitis expressed syndecan-4. Glypican was expressed only by macrophages. Stimulation of PBMC with mitogens and growth factors modulated syndecan-1 expression in both the T- and B-cells. Thus, cell-surface proteoglycan expression by lymphocytes in periodontal inflammation is cell-type-specific and may be modulated by inflammation. |
Keywords: | B-Lymphocytes Plasma Cells Lymphocytes T-Lymphocytes Macrophages Gingiva Tooth Cervix Humans Alveolar Bone Loss Gingival Hemorrhage Gingivitis Periodontal Attachment Loss Periodontitis Periodontal Pocket Chronic Disease Proteoglycans Growth Substances Membrane Glycoproteins Mitogens Flow Cytometry Analysis of Variance Regression Analysis Adult Aged Middle Aged Female Male Heparan Sulfate Proteoglycans Syndecan-1 Syndecans Syndecan-4 Statistics as Topic |
Rights: | Copyright © 2001 by International & American Associations for Dental Research Online Journals |
DOI: | 10.1177/00220345010800080501 |
Published version: | http://dx.doi.org/10.1177/00220345010800080501 |
Appears in Collections: | Aurora harvest Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.