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https://hdl.handle.net/2440/40011
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dc.contributor.author | Manakil, J. | - |
dc.contributor.author | Sugerman, P. | - |
dc.contributor.author | Li, H. | - |
dc.contributor.author | Seymour, G. | - |
dc.contributor.author | Bartold, P. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Journal of Dental Research, 2001; 80(8):1704-1710 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.issn | 1544-0591 | - |
dc.identifier.uri | http://hdl.handle.net/2440/40011 | - |
dc.description.abstract | Cell-surface proteoglycans are involved in lymphocyte migration and activation. This study investigated the expression of syndecan-1, syndecan-4, and glypican in peripheral blood lymphocytes and by lymphocytes in variously inflamed periodontal tissues. Gingival specimens from healthy, gingivitis, or chronic periodontitis sites were stained by means of antibodies against B- and T-lymphocytes and also syndecan-1, syndecan-4, and glypican. Syndecan-1 expression by peripheral blood mononuclear cells (PBMC) from healthy, gingivitis, and chronic periodontitis subjects was assessed by flow cytometry. Syndecan-1 was expressed by B-cells/plasma cells but not T-cells in both gingivitis and chronic periodontitis lesions. Both B-cells/plasma cells and T-cells in gingivitis and chronic periodontitis expressed syndecan-4. Glypican was expressed only by macrophages. Stimulation of PBMC with mitogens and growth factors modulated syndecan-1 expression in both the T- and B-cells. Thus, cell-surface proteoglycan expression by lymphocytes in periodontal inflammation is cell-type-specific and may be modulated by inflammation. | - |
dc.description.statementofresponsibility | J. F. Manakil, P. B. Sugerman, H. Li, G. J. Seymour and P. M. Bartold | - |
dc.language.iso | en | - |
dc.publisher | Inter Amer Assoc Dental Research | - |
dc.rights | Copyright © 2001 by International & American Associations for Dental Research Online Journals | - |
dc.source.uri | http://dx.doi.org/10.1177/00220345010800080501 | - |
dc.subject | B-Lymphocytes | - |
dc.subject | Plasma Cells | - |
dc.subject | Lymphocytes | - |
dc.subject | T-Lymphocytes | - |
dc.subject | Macrophages | - |
dc.subject | Gingiva | - |
dc.subject | Tooth Cervix | - |
dc.subject | Humans | - |
dc.subject | Alveolar Bone Loss | - |
dc.subject | Gingival Hemorrhage | - |
dc.subject | Gingivitis | - |
dc.subject | Periodontal Attachment Loss | - |
dc.subject | Periodontitis | - |
dc.subject | Periodontal Pocket | - |
dc.subject | Chronic Disease | - |
dc.subject | Proteoglycans | - |
dc.subject | Growth Substances | - |
dc.subject | Membrane Glycoproteins | - |
dc.subject | Mitogens | - |
dc.subject | Flow Cytometry | - |
dc.subject | Analysis of Variance | - |
dc.subject | Regression Analysis | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Heparan Sulfate Proteoglycans | - |
dc.subject | Syndecan-1 | - |
dc.subject | Syndecans | - |
dc.subject | Syndecan-4 | - |
dc.subject | Statistics as Topic | - |
dc.title | Cell-surface proteoglycan expression by lymphocytes from peripheral blood and gingiva in health and periodontal disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1177/00220345010800080501 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bartold, P. [0000-0002-5695-3877] | - |
Appears in Collections: | Aurora harvest Dentistry publications |
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