Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/28202
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DC Field | Value | Language |
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dc.contributor.author | Groth, C. | - |
dc.contributor.author | Nornes, S. | - |
dc.contributor.author | Mc Carty, R. | - |
dc.contributor.author | Tamme, R. | - |
dc.contributor.author | Lardelli, M. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Development, Genes and Evolution, 2002; 212(10):486-490 | - |
dc.identifier.issn | 0949-944X | - |
dc.identifier.issn | 1432-041X | - |
dc.identifier.uri | http://hdl.handle.net/2440/28202 | - |
dc.description | © Springer-Verlag 2002 The original publication can be found at www.springerlink.com | - |
dc.description.abstract | Presenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes. | - |
dc.description.statementofresponsibility | Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.source.uri | http://www.springerlink.com/content/pne2xqatmd1kjga5/ | - |
dc.subject | Presenilin | - |
dc.subject | Neural crest | - |
dc.subject | Zebrafish | - |
dc.subject | Alzheimer’s disease | - |
dc.subject | Melanocyte | - |
dc.title | Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2 | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1007/s00427-002-0269-5 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lardelli, M. [0000-0002-4289-444X] | - |
Appears in Collections: | Aurora harvest 2 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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