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https://hdl.handle.net/2440/28202
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Type: | Journal article |
Title: | Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2 |
Author: | Groth, C. Nornes, S. Mc Carty, R. Tamme, R. Lardelli, M. |
Citation: | Development, Genes and Evolution, 2002; 212(10):486-490 |
Publisher: | Springer |
Issue Date: | 2002 |
ISSN: | 0949-944X 1432-041X |
Organisation: | Centre for the Molecular Genetics of Development |
Statement of Responsibility: | Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli |
Abstract: | Presenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes. |
Keywords: | Presenilin Neural crest Zebrafish Alzheimer’s disease Melanocyte |
Description: | © Springer-Verlag 2002 The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s00427-002-0269-5 |
Published version: | http://www.springerlink.com/content/pne2xqatmd1kjga5/ |
Appears in Collections: | Aurora harvest 2 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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