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https://hdl.handle.net/2440/17289
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Type: | Journal article |
Title: | Adipokines: implications for female fertility and obesity |
Author: | Mitchell, M. Armstrong, D. Robker, R. Norman, R. |
Citation: | Reproduction, 2005; 130(5):583-597 |
Publisher: | Bio Scientifica Ltd |
Issue Date: | 2005 |
ISSN: | 1470-1626 1741-7899 |
Statement of Responsibility: | M. Mitchell, D. T. Armstrong, R. L. Robker and R. J. Norman |
Abstract: | Obesity is associated with a diverse set of metabolic disorders, and has reproductive consequences that are complex and not well understood. The adipose tissue-produced leptin has dominated the literature with regards to female fertility complications, but it is pertinent to explore the likely role of other adipokines – adiponectin and resistin – as our understanding of their biological functions emerge. Leptin influences the developing embryo, the functioning of the ovary and the endometrium, interacts with the release and activity of gonadotrophins and the hormones that control their synthesis. In this review such biological actions and potential roles of the adipokines leptin, adiponectin and resistin are explored in relation to female fertility and the complexity of the obese metabolic state. |
Keywords: | Adipose Tissue Animals Mice, Knockout Humans Mice Infertility, Female Insulin Resistance Obesity Insulin Leptin Blood Glucose Models, Animal Pregnancy Female Adiponectin Resistin |
Description: | © 2005 Society for Reproduction and Fertility |
DOI: | 10.1530/rep.1.00521 |
Published version: | http://www.reproduction-online.org/cgi/content/abstract/130/5/583 |
Appears in Collections: | Aurora harvest 6 Obstetrics and Gynaecology publications |
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