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https://hdl.handle.net/2440/132795
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Type: | Journal article |
Title: | Breast milk feeding, brain development, and neurocognitive outcomes: a 7-year longitudinal study in infants born at less than 30 weeks' gestation |
Author: | Belfort, M.B. Anderson, P.J. Nowak, V.A. Lee, K.J. Molesworth, C. Thompson, D.K. Doyle, L.W. Inder, T.E. |
Citation: | Journal of Pediatrics, 2016; 177:133-139 |
Publisher: | Elsevier |
Issue Date: | 2016 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Mandy B.Belfort, Peter J.Anderson, Victoria A.Nowak, Katherine J.Lee, Charlotte Molesworth, Deanne K.Thompson ... et al. |
Abstract: | Objectives: To determine the associations of breast milk intake after birth with neurological outcomes at term equivalent and 7 years of age in very preterm infants Study design: We studied 180 infants born at <30 weeks' gestation or <1250 grams birth weight enrolled in the Victorian Infant Brain Studies cohort from 2001-2003. We calculated the number of days on which infants received >50% of enteral intake as breast milk from 0-28 days of life. Outcomes included brain volumes measured by magnetic resonance imaging at term equivalent and 7 years of age, and cognitive (IQ, reading, mathematics, attention, working memory, language, visual perception) and motor testing at 7 years of age. We adjusted for age, sex, social risk, and neonatal illness in linear regression. Results: A greater number of days on which infants received >50% breast milk was associated with greater deep nuclear gray matter volume at term equivalent age (0.15 cc/d; 95% CI, 0.05-0.25); and with better performance at age 7 years of age on IQ (0.5 points/d; 95% CI, 0.2-0.8), mathematics (0.5; 95% CI, 0.1-0.9), working memory (0.5; 95% CI, 0.1-0.9), and motor function (0.1; 95% CI, 0.0-0.2) tests. No differences in regional brain volumes at 7 years of age in relation to breast milk intake were observed. Conclusion: Predominant breast milk feeding in the first 28 days of life was associated with a greater deep nuclear gray matter volume at term equivalent age and better IQ, academic achievement, working memory, and motor function at 7 years of age in very preterm infants. |
Keywords: | academic achievement; intelligence; magnetic resonance imaging; memory; preterm infant |
Rights: | © 2016 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jpeds.2016.06.045 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/546519 http://purl.org/au-research/grants/nhmrc/1060733 http://purl.org/au-research/grants/nhmrc/237117 http://purl.org/au-research/grants/nhmrc/491209 http://purl.org/au-research/grants/nhmrc/1081288 http://purl.org/au-research/grants/nhmrc/1012236 http://purl.org/au-research/grants/nhmrc/1053787 http://purl.org/au-research/grants/nhmrc/1085754 http://purl.org/au-research/grants/nhmrc/1053609 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2016.06.045 |
Appears in Collections: | Paediatrics publications |
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