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https://hdl.handle.net/2440/11793
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Type: | Journal article |
Title: | Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women |
Author: | Heilbronn, L. Kind, K. Pancewicz, E. Coates, A. Noakes, M. Clifton, P. |
Citation: | Diabetologia, 2000; 43(2):242-244 |
Publisher: | Springer |
Issue Date: | 2000 |
ISSN: | 0012-186X 1432-0428 |
Abstract: | <h4>Aims/hypothesis</h4>To determine whether genetic variation in uncoupling protein-1 (UCP-1) is associated with obesity or obesity-related risk factors in overweight women.<h4>Methods</h4>We genotyped 526 overweight/obese women (mean body mass index 34.1 kg/m2, range 25.0 to 47.5 kg/m2) for the -3826 A-->G uncoupling protein-1 polymorphism. Of the 526 women genotyped 144 had fasting blood samples analysed for glucose and lipid measurements.<h4>Results</h4>The -3826 G allele was found with a frequency of 0.23 and was associated with higher BMI (p = 0.02). A higher frequency of this polymorphism (0.33) was found in subjects with Type II (non-insulin-dependent) diabetes mellitus (p = 0.02), though adjustment for BMI weakened this significance (p = 0.06). The -3826 G variant was associated with increased fasting glucose (p = 0.01). This was, however, a result of a greater proportion of women with Type II diabetes also having the G variant (p = 0.10, adjusted for Type II diabetes). The -3826 G variant of uncoupling protein-1 did not have an effect on other metabolic variables associated with obesity.<h4>Conclusion/interpretation</h4>In overweight Australian women the -3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation. |
Keywords: | Humans Diabetes Mellitus Diabetes Mellitus, Type 2 Obesity Carrier Proteins Ion Channels Membrane Proteins Mitochondrial Proteins Body Mass Index Polymorphism, Genetic Alleles Middle Aged Australia Female Genetic Variation Uncoupling Protein 1 White People |
DOI: | 10.1007/s001250050036 |
Published version: | http://dx.doi.org/10.1007/s001250050036 |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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