Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: C-Reactive protein: higher during acute psychotic episodes and related to cortical thickness in schizophrenia and healthy controls
Author: Jacomb, I.
Stanton, C.
Vasudevan, R.
Powell, H.
O'Donnell, M.
Lenroot, R.
Bruggemann, J.
Balzan, R.
Galletly, C.
Liu, D.
Weickert, C.
Weickert, T.
Citation: Frontiers in Immunology, 2018; 9(OCT):2230-1-2230-16
Publisher: Frontiers Media SA
Issue Date: 2018
ISSN: 1664-3224
Statement of
Isabella Jacomb, Clive Stanton, Rohini Vasudevan, Hugh Powell, Maryanne O’Donnell, Rhoshel Lenroot, Jason Bruggemann, Ryan Balzan, Cherrie Galletly, Dennis Liu, Cynthia S. Weickert and Thomas W. Weickert
Abstract: There is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical thickness, a measure of the degree of neuropathology, are unknown. In independent samples, we assessed the peripheral inflammation marker C-reactive protein (CRP) to determine the extent to which: (1) CRP was elevated and stable across admissions for acute psychosis, (2) cognition, daily function and symptom severity are characteristic of chronically ill patients with schizophrenia displaying elevated CRP, and (3) CRP levels predict cortical thickness. Study 1 assessed peripheral CRP (primary outcome) and other blood measures in 174/280 people with acute psychosis while Study 2 assessed peripheral CRP, cognition and cortical thickness (primary outcomes), symptoms, and daily function in 85/97 chronically ill patients with schizophrenia and 71/87 healthy controls. In acute psychosis, CRP and neutrophil-to-lymphocyte ratio were significantly elevated relative to a normal cutoff (with 59.8% of patients having elevated CRP) which remained elevated across admissions. CRP was significantly elevated in 43% of chronically ill patients with schizophrenia compared to 20% in controls. Elevated CRP patients displayed significantly worse working memory and CRP was inversely correlated with cortical thickness in frontal, insula, and temporal brain regions. This work supports the role of inflammation in psychotic illnesses and suggests that use of peripheral markers (e.g., CRP) in conjunction with diagnosis could be used to identify patients with more cortical neuropathology and cognitive deficits.
Keywords: Schizophrenia; acute psychosis; c-reactive protein; cortical thickness; inflammation; working memory; cognition; CRP
Rights: Copyright © 2018 Jacomb, Stanton, Vasudevan, Powell, O’Donnell, Lenroot, Bruggemann, Balzan, Galletly, Liu, Weickert and Weickert. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fimmu.2018.02230
Grant ID:
Appears in Collections:Aurora harvest 8
Psychology publications

Files in This Item:
File Description SizeFormat 
hdl_117391.pdfPublished version481.46 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.