Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113046
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | CRLF2-positive B-cell acute lymphoblastic leukemia in adult patients : a single-institution experience |
Author: | Konoplev, S. Lu, X. Konopleva, M. Jain, N. Ouyang, J. Goswami, M. Roberts, K. Valentine, M. Mullighan, C. Bueso-Ramos, C. Zweidler-McKay, P. Jorgensen, J. Wang, S. |
Citation: | American Journal of Clinical Pathology, 2017; 147(4):357-363 |
Publisher: | American Society for Clinical Pathology |
Issue Date: | 2017 |
ISSN: | 0002-9173 1943-7722 |
Statement of Responsibility: | Sergej Konoplev, Xinyan Lu, Marina Konopleva, Nitin Jain, Juan Ouyang … Charles G. Mullighan … et al. |
Abstract: | Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. We analyzed CRLF2 expression and studied its correlation with CRLF2 rearrangement in adult patients with B-ALL.Multiparameter flow cytometry (MFC) was performed consecutively in 126 patients.CRLF2 overexpression was detected in 30 (27%) patients, 28 (41%) of 69 patients with B-ALL not otherwise specified, 14 (21%) of 67 untreated patients, and 16 (27%) of 59 patients with relapsed B-ALL, with the highest among Hispanic patients (25/55, 45%). Of CRLF2+ cases, 21 (100%) of 21 cases showed CRLF2 rearrangement by fluorescence in situ hybridization, preferentially involving IGH@CRLF2 (15/15). The entire coding region of JAK2 was sequenced in 14 patients with CRLF2+ B-ALL, and nine (64%) were positive for JAK2 mutations.MFC allows a rapid, inexpensive, and reliable detection of B-ALL with CRLF2 rearrangement that would further facilitate testing for JAK2 mutations for targetable therapy. |
Keywords: | B-lymphoblastic leukemia/lymphoma; BCR-ABL1–like; Ph-like B-ALL; CRLF2; Flow cytometry; FISH; JAK2 mutation |
Rights: | © American Society for Clinical Pathology, 2017. All rights reserved. |
DOI: | 10.1093/AJCP/AQX005 |
Published version: | http://dx.doi.org/10.1093/ajcp/aqx005 |
Appears in Collections: | Aurora harvest 3 Genetics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.