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https://hdl.handle.net/2440/103741
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Type: | Journal article |
Title: | Prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial |
Author: | Best, K.P. Sullivan, T. Palmer, D. Gold, M. Kennedy, D.J. Martin, J. Makrides, M. |
Citation: | Pediatrics, 2016; 137(6):1-9 |
Publisher: | American Academy of Pediatrics |
Issue Date: | 2016 |
ISSN: | 0031-4005 1098-4275 |
Statement of Responsibility: | Karen P. Best, Thomas Sullivan, Michael Gold, Declan (John) Kennedy, James Martin, Maria Makrides |
Abstract: | Background and Objective: Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy. Methods: Six-year follow-up of children (n = 706) with a family history of allergic disease from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial. Women were randomly allocated to receive n-3 LCPUFA-rich fish oil capsules (800 mg/d docosahexaenoic acid DHA and 100mg/d eicosapentaenoic acid) or vegetable oil capsules (without n-3 LCPUFA). Allergic disease symptoms including eczema, wheeze, rhinitis, and rhino-conjunctivitis, were assessed using the International Study of Asthma and Allergies in Childhood questionnaire and sensitization to allergens was measured by skin prick test. Results: There was no difference in the percentage of children with any IgE-associated allergic disease between the n-3 LCPUFA and control groups (116/367 [31.5%] vs 106/336 [31.5%]; adjusted relative risk, 1.04; 95% confidence interval, 0.82-1.33; P = .73). There was a reduction in the percentage of children sensitized to house dust mite Dermatophagoides farinae (49/367 [13.4%] vs 68/336 [20.3%]; adjusted relative risk, 0.67, 95% confidence interval, 0.44-1.00; P = .0495). Conclusions: Prenatal n-3 LCPUFA supplementation did not reduce IgE-associated allergic disease at 6 years of age. Secondary outcomes were suggestive of a protective effect of the intervention on the incidence of D. farinae sensitization. |
Keywords: | Animals Humans Dermatophagoides farinae Prenatal Exposure Delayed Effects Hypersensitivity Docosahexaenoic Acids Eicosapentaenoic Acid Immunoglobulin E Prenatal Care Follow-Up Studies Pregnancy Dietary Supplements Adult Child Female Male |
Rights: | Copyright © 2016 by the American Academy of Pediatrics. All rights reserved. |
DOI: | 10.1542/peds.2015-4443 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1061704 http://purl.org/au-research/grants/nhmrc/1027710 |
Published version: | http://dx.doi.org/10.1542/peds.2015-4443 |
Appears in Collections: | Aurora harvest 3 Paediatrics publications |
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