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https://hdl.handle.net/2440/98653
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Type: | Journal article |
Title: | Serum 25-hydroxyvitamin D₃ and D₂ and non-clinical psychotic experiences in childhood |
Other Titles: | Serum 25-hydroxyvitamin D(3) and D(2) and non-clinical psychotic experiences in childhood |
Author: | Tolppanen, A. Sayers, A. Fraser, W. Lewis, G. Zammit, S. McGrath, J. Lawlor, D. |
Citation: | PLoS One, 2012; 7(7):e41575-1-e41575-8 |
Publisher: | Public Library of Science |
Issue Date: | 2012 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Hashimoto, K. |
Statement of Responsibility: | Anna-Maija Tolppanen, Adrian Sayers, William D. Fraser, Glyn Lewis, Stanley Zammit, John McGrath, Debbie A. Lawlor |
Abstract: | Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D(3) and 25(OH)D(2), have similar associations with psychosis-related outcomes.We investigated the association between serum 25(OH)D(3) and 25(OH)D(2) concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D(3) and 25(OH)D(2) concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).Higher 25(OH)D(3) concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D(2) were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D(2) concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.Our findings of an inverse association of 25(OH)D(3) with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes. |
Keywords: | Calcifediol 25-Hydroxyvitamin D 2 Follow-Up Studies Prospective Studies Psychotic Disorders |
Rights: | © 2012 Tolppanen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0041575 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0041575 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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