Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97375
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Type: Journal article
Title: Effect of Critical Illness on Triglyceride Absorption
Author: Ali Abdelhamid, Y.
Cousins, C.
Sim, J.
Bellon, M.
Nguyen, N.
Horowitz, M.
Chapman, M.
Deane, A.
Citation: Journal of Parenteral and Enteral Nutrition, 2015; 39(8):966-972
Publisher: SAGE Publications
Issue Date: 2015
ISSN: 0148-6071
1941-2444
Statement of
Responsibility: 
Yasmine Ali Abdelhamid, Caroline E. Cousins, Jennifer A. Sim, Max S. Bellon, Nam Q. Nguyen, Michael Horowitz, Marianne J. Chapman and Adam M. Deane
Abstract: Adequate nutrition support for critically ill patients optimizes outcome, and enteral feeding is the preferred route of nutrition. Small intestinal glucose absorption is frequently impaired in critical illness. Despite lipid being a major constituent of liquid nutrient administered, there is little information about lipid absorption during critical illness.To determine small intestinal lipid, as well as glucose, absorption in critical illness compared with health.Twenty-nine mechanically ventilated critically ill patients and 16 healthy volunteers were studied. Liquid nutrient (60 mL, 1 kcal/mL), containing 200 µL ¹³C-triolein and 3 g 3-O-methyl-glucose (3-OMG), was infused directly into the duodenum at a rate of 2 kcal/min. Exhaled ¹³CO₂ and serum 3-OMG concentrations were measured at timed intervals over 360 minutes. Lipid absorption was measured as the cumulative percentage dose (cPDR) of ¹³CO₂ recovered at 360 minutes. Glucose absorption was measured as the area under the 3-OMG concentration curve. Data are median (range) and analyzed using the Mann-Whitney U and Pearson correlation tests.Lipid absorption was markedly less in the critically ill (cPDR¹³CO₂: patients, 22.6% [0%-100%] vs healthy participants, 40.7% [5.3%-84.7%]; P = .018). While glucose absorption was less at 60 minutes in the critically ill (3-OMG60: 13.2 [3.5-29.5] vs 21.1 [9.3-31.9] mmol/L·min; P = .003), this was not apparent at 360 minutes (3-OMG360: 92.7 [54.5-147.9] vs 107.9 [64.0-168.7] mmol/L·min; P = .126). There was no relationship between lipid and glucose absorption.Small intestinal absorption of lipid is diminished during critical illness.
Keywords: Lipids; nutrition; critical care; research and diseases; enteral nutrition
Rights: © 2014 American Society for Parenteral and Enteral Nutrition
RMID: 0030011338
DOI: 10.1177/0148607114540214
Appears in Collections:Medicine publications

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