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https://hdl.handle.net/2440/96908
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Type: | Journal article |
Title: | Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies |
Author: | Elks, C. Perry, J. Sulem, P. Chasman, D. Franceschini, N. He, C. Lunetta, K. Visser, J. Byrne, E. Cousminer, D. Gudbjartsson, D. Esko, T. Feenstra, B. Hottenga, J. Koller, D. Kutalik, Z. Lin, P. Mangino, M. Marongiu, M. McArdle, P. et al. |
Citation: | Nature Genetics, 2010; 42(12):1077-1085 |
Publisher: | Nature Publishing Group |
Issue Date: | 2010 |
ISSN: | 1061-4036 1546-1718 |
Statement of Responsibility: | Cathy E Elks ... The GIANT Consortium ... Lyle J Palmer ... et al. |
Abstract: | To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10−60) and 9q31.2 (P = 2.2 × 10−33), we identified 30 new menarche loci (all P < 5 × 10−8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10−6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. |
Keywords: | GIANT Consortium Humans Obesity Genetic Predisposition to Disease Body Size Body Height Reproducibility of Results Aging Menarche Inheritance Patterns Polymorphism, Single Nucleotide Quantitative Trait Loci Time Factors Adolescent Child Female Genome-Wide Association Study Genetic Loci DNA Copy Number Variations |
Rights: | © 2010 Nature America, Inc. All rights reserved |
DOI: | 10.1038/ng.714 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/241944 http://purl.org/au-research/grants/nhmrc/339462 http://purl.org/au-research/grants/nhmrc/389927 http://purl.org/au-research/grants/nhmrc/389875 http://purl.org/au-research/grants/nhmrc/389891 http://purl.org/au-research/grants/nhmrc/389892 http://purl.org/au-research/grants/nhmrc/389938 http://purl.org/au-research/grants/nhmrc/442915 http://purl.org/au-research/grants/nhmrc/442981 http://purl.org/au-research/grants/nhmrc/496739 http://purl.org/au-research/grants/nhmrc/552485 http://purl.org/au-research/grants/nhmrc/552498 http://purl.org/au-research/grants/nhmrc/619667 http://purl.org/au-research/grants/arc/A7960034 http://purl.org/au-research/grants/arc/A79801419 http://purl.org/au-research/grants/arc/A79906588 http://purl.org/au-research/grants/arc/DP0212016 http://purl.org/au-research/grants/arc/DP0343921 http://purl.org/au-research/grants/arc/DP0770096 |
Published version: | http://dx.doi.org/10.1038/ng.714 |
Appears in Collections: | Aurora harvest 7 Public Health publications |
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