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https://hdl.handle.net/2440/9510
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dc.contributor.author | Brand, C. | - |
dc.contributor.author | Grimbaldeston, M. | - |
dc.contributor.author | Gamble, J. | - |
dc.contributor.author | Drew, J. | - |
dc.contributor.author | Finlay-Jones, J. | - |
dc.contributor.author | Hart, P. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Inflammation Research, 2002; 51(5):236-244 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.issn | 1420-908X | - |
dc.identifier.uri | http://hdl.handle.net/2440/9510 | - |
dc.description.abstract | <h4>Objective</h4>To examine the anti-inflammatory activities of tea tree oil (TTO) in vivo.<h4>Methods</h4>Mice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin with the same hapten.<h4>Results</h4>TTO applied 30 min before or up to 7 h after to the same dorsal site as hapten challenge caused a significant reduction in skin swelling after 24 h. TTO reduced oedema but not the influx of inflammatory cells. This finding was supported by the inability of TTO to suppress TNFalpha-induced E-selectin expression by human umbilical vein endothelial cells. TTO did not suppress irritant- or ultraviolet B-induced oedema.<h4>Conclusion</h4>Topical TTO, specifically the TTO components, terpinen-4-ol and alpha-terpineol can regulate the oedema associated with the efferent phase of a contact hypersensitivity response. | - |
dc.description.statementofresponsibility | C. Brand, M. A. Grimbaldeston, J. R. Gamble, J. Drew, J. J. Finlay-Jones, P. H. Hart | - |
dc.language.iso | en | - |
dc.publisher | Birkhauser Verlag Ag | - |
dc.source.uri | http://dx.doi.org/10.1007/pl00000299 | - |
dc.subject | Endothelium, Vascular | - |
dc.subject | Cells, Cultured | - |
dc.subject | Skin | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Dermatitis, Allergic Contact | - |
dc.subject | Edema | - |
dc.subject | Picryl Chloride | - |
dc.subject | Hematoxylin | - |
dc.subject | Eosine Yellowish-(YS) | - |
dc.subject | Tea Tree Oil | - |
dc.subject | Cell Adhesion Molecules | - |
dc.subject | Fluorescent Dyes | - |
dc.subject | Ultraviolet Rays | - |
dc.subject | Coloring Agents | - |
dc.subject | Female | - |
dc.title | Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/PL00000299 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Medicine publications |
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