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https://hdl.handle.net/2440/9496
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Type: | Journal article |
Title: | Role of BCL-2 family of proteins in malignancy |
Author: | Baliga, B. Kumar, S. |
Citation: | Hematological Oncology, 2002; 20(2):63-74 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2002 |
ISSN: | 0278-0232 1099-1069 |
Statement of Responsibility: | Belinda C. Baliga, Sharad Kumar |
Abstract: | B cell lymphoma gene-2 (Bcl-2) is the prototypic member of a growing family of proteins that play evolutionarily conserved, key regulatory roles in apoptosis. The Bcl-2 family members are characterized by the presence of one or more Bcl-2 homology domains and are comprised of both the prosurvival and proapoptotic proteins. Bcl-2 itself is a prosurvival member of the family and its aberrant expression has been linked to a variety of different cancers, including several hematological malignancies. Although the exact mechanism of action of Bcl-2 family of proteins in regulating apoptosis is still a matter of some debate, these proteins appear to act upstream of caspase activation. Many recent studies have shown the therapeutic potential of targeting Bcl-2 family members for the treatment of cancer. This article summarizes what is currently known about Bcl-2-like proteins and how the evolving understanding of the biology of these proteins is paving way for the development of novel cancer therapeutics. |
Keywords: | Humans Neoplasms Proto-Oncogene Proteins c-bcl-2 Apoptosis |
Description: | Copyright © 2008 John Wiley & Sons, Ltd. |
Provenance: | Published Online: 4 Dec 2001 |
DOI: | 10.1002/hon.685 |
Published version: | http://dx.doi.org/10.1002/hon.685 |
Appears in Collections: | Aurora harvest Medicine publications |
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