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https://hdl.handle.net/2440/9291
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dc.contributor.author | Shearwin-Whyatt, L. | - |
dc.contributor.author | Baliga, B. | - |
dc.contributor.author | Doumanis, J. | - |
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2001; 282(5):1114-1119 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9291 | - |
dc.description | Copyright © 2001 Academic Press. All rights reserved. | - |
dc.description.abstract | Cellular defects which prevent apoptotic cell death can result in the generation of hyperproliferative disorders and can prevent the effective treatment of such diseases. The majority of cellular defects which result in apoptosis resistance lie upstream of caspase activation. We have described chimeric caspase molecules consisting of the prodomain of caspase-2 fused to the amino terminus of caspase-3, and which are tagged at the carboxyl terminus with green fluorescent protein (GFP) to allow direct visualisation of transfected cells. Here we show that these chimeric caspase molecules possess potent, rapid cell-killing activity in cell lines which display a range of defects resulting in apoptosis resistance. | - |
dc.description.statementofresponsibility | Linda Shearwin-Whyatt, Belinda Baliga, Joanna Doumanis and Sharad Kumar | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description#description | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc | - |
dc.source.uri | http://dx.doi.org/10.1006/bbrc.2001.4699 | - |
dc.subject | COS Cells | - |
dc.subject | Tumor Cells, Cultured | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Leukemia, T-Cell | - |
dc.subject | Osteosarcoma | - |
dc.subject | Caspases | - |
dc.subject | Luminescent Proteins | - |
dc.subject | Green Fluorescent Proteins | - |
dc.subject | Recombinant Fusion Proteins | - |
dc.subject | Transfection | - |
dc.subject | Drug Resistance, Multiple | - |
dc.subject | Apoptosis | - |
dc.subject | Cell Survival | - |
dc.subject | Drug Resistance, Neoplasm | - |
dc.subject | Caspase 3 | - |
dc.subject | Caspase 2 | - |
dc.subject | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | - |
dc.subject | ATP Binding Cassette Transporter, Subfamily B, Member 1 | - |
dc.title | Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1006/bbrc.2001.4699 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Shearwin-Whyatt, L. [0000-0002-4504-6534] | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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