Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/88175
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The Tasmanian Devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer |
Author: | Murchison, E. Tovar, C. Hsu, A. Bender, H. Kheradpour, P. Rebbeck, C. Obendorf, D. Conlan, C. Bahlo, M. Blizzard, C. Pyecroft, S. Kreiss, A. Kellis, M. Stark, A. Harkins, T. Graves, J. Woods, G. Hannon, G. Papenfuss, A. |
Citation: | Science, 2010; 327(5961):84-87 |
Publisher: | American Association for the Advancement of Science |
Issue Date: | 2010 |
ISSN: | 0036-8075 1095-9203 |
Statement of Responsibility: | Elizabeth P. Murchison, Cesar Tovar, Arthur Hsu, Hannah S. Bender, Pouya Kheradpour, Clare A. Rebbeck, David Obendorf, Carly Conlan, Melanie Bahlo, Catherine A. Blizzard, Stephen Pyecroft, Alexandre Kreiss, Manolis Kellis, Alexander Stark, Timothy T. Harkins, Jennifer A. Marshall Graves, Gregory M. Woods, Gregory J. Hannon, Anthony T. Papenfuss |
Abstract: | The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology. |
Keywords: | Schwann Cells Animals Marsupialia Facial Neoplasms Bites and Stings Membrane Proteins MicroRNAs Gene Expression Profiling Sequence Analysis, DNA Cell Differentiation Gene Expression Regulation, Neoplastic Microsatellite Repeats Genotype Nerve Sheath Neoplasms Genes, Neoplasm Genome, Mitochondrial Myelin Basic Protein Biomarkers, Tumor |
Rights: | © 2010 by the American Association for the Advancement of Science |
DOI: | 10.1126/science.1180616 |
Published version: | http://dx.doi.org/10.1126/science.1180616 |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 2 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.