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https://hdl.handle.net/2440/8815
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Type: | Journal article |
Title: | Tolerance induction by transdermal glyceryl trinitrate in rats |
Author: | de la Lande, I. Stafford, I. Horowitz, J. |
Citation: | European Journal of Pharmacology, 1999; 374(1):71-75 |
Publisher: | ELSEVIER SCIENCE BV |
Issue Date: | 1999 |
ISSN: | 0014-2999 1879-0712 |
Abstract: | Mechanisms of mild glyceryl trinitrate tolerance in rats (transdermal application; 15 mg/day/2 days) were examined in isolated aortic rings contracted with phenylephrine. Tolerance to glyceryl trinitrate was comparable in both endothelium-intact and -denuded vessels; the maximum relaxation decreased to 70-80% and the EC50 increased 3-4-fold. There was minimal cross-tolerance to acetylcholine (1.7-fold increase in EC50) and none to sodium nitroprusside. The results suggest that mild tolerance to glyceryl trinitrate in rats is mediated by mechanisms which are predominantly endothelium-independent and which produce little activation of the cellular mechanism responsible for cross-tolerance. |
Keywords: | Aorta Animals Rats Rats, Sprague-Dawley Nitroprusside Phenylephrine Nitroglycerin Acetylcholine Vasodilator Agents Administration, Cutaneous Vasodilation Dose-Response Relationship, Drug Drug Tolerance Male In Vitro Techniques |
DOI: | 10.1016/S0014-2999(99)00319-2 |
Published version: | http://dx.doi.org/10.1016/s0014-2999(99)00319-2 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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