Adelaide Research & Scholarship
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https://hdl.handle.net/2440/87807
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| Type: | Journal article |
| Title: | Markers of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum in placenta and circulation of pregnant women |
| Author: | Mockenhaupt, F.P. Bedu-Addo, G. Junge, C. Hommerich, L. Eggelte, T.A. Bienzle, U. |
| Citation: | Antimicrobial Agents and Chemotherapy, 2007; 51(1):332-334 |
| Publisher: | American Society for Microbiology |
| Issue Date: | 2007 |
| ISSN: | 0066-4804 1098-6596 |
| Statement of Responsibility: | Frank P. Mockenhaupt, George Bedu-Addo, Claudia Junge, Lena Hommerich, Teunis A. Eggelte, and Ulrich Bienzle |
| Abstract: | Placental sequestration of Plasmodium falciparum in pregnancy may impair the usefulness of molecular markers of sulfadoxine-pyrimethamine resistance. In 300 infected, delivering women, the concordance of PCR-restriction fragment length polymorphism-derived parasite resistance alleles in matched samples from placenta and circulation was 83 to 98%. Sulfadoxine-pyrimethamine resistance typing in peripheral blood is reasonably representative of P. falciparum infecting pregnant women. |
| Keywords: | Placenta Animals Humans Plasmodium falciparum Pregnancy Complications, Parasitic Malaria, Falciparum Sulfadoxine Pyrimethamine Tetrahydrofolate Dehydrogenase Drug Combinations Antimalarials Polymerase Chain Reaction Pregnancy Drug Resistance Genotype Mutation Polymorphism, Restriction Fragment Length Adolescent Adult Middle Aged Female Biomarkers |
| Rights: | Copyright © 2007, American Society for Microbiology |
| DOI: | 10.1128/AAC.00856-06 |
| Published version: | http://dx.doi.org/10.1128/aac.00856-06 |
| Appears in Collections: | Aurora harvest 2 Ecology, Evolution and Landscape Science publications |
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