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https://hdl.handle.net/2440/86558
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Type: | Journal article |
Title: | Management of hot flashes in patients who have breast cancer with Venlafaxine and Clonidine: a randomized, double-blind, placebo-controlled trial |
Author: | Boekhout, A. Vincent, A. Dalesio, O. van den Bosch, J. Foekema-Tons, J. Adriaansz, S. Sprangers, S. Nuijen, B. Beijnen, J. Schellens, J. |
Citation: | Journal of Clinical Oncology, 2011; 29(29):3862-3868 |
Publisher: | American Society of Clinical Oncology |
Issue Date: | 2011 |
ISSN: | 0732-183X 1527-7755 |
Statement of Responsibility: | Annelies H. Boekhout, Andrew D. Vincent, Otilia B. Dalesio, Joan van den Bosch, Joke H. Foekema-Töns, Sandra Adriaansz, Sylvia Sprangers, Bastiaan Nuijen, Jos H. Beijnen, and Jan H.M. Schellens |
Abstract: | Purpose: Therapies for breast cancer may induce hot flashes that can affect quality of life. We undertook a double-blind, placebo-controlled trial with the primary objective of comparing the average daily hot flash scores in the twelfth week among patients treated with venlafaxine, clonidine, and placebo. Additional analyses of the hot flash score over the full 12 weeks of treatment were performed. Patients and Methods: In all, 102 patients with a history of breast cancer were randomly assigned (2:2:1) to venlafaxine 75 mg, clonidine 0.1 mg, or placebo daily for 12 weeks. Questionnaires at baseline and during treatment assessed daily hot flash scores, sexual function, sleep quality, anxiety, and depression. Results: After 12 weeks, a total of 80 patients were evaluable for the primary end point. During week 12, hot flash scores were significantly lower in the clonidine group versus placebo (P = .03); for venlafaxine versus placebo, the difference was borderline not significant (P = .07). However, hot flash scores were equal in the clonidine and venlafaxine groups. Over the course of 12 weeks, the differences between both treatments and placebo were significant (P <.001 for venlafaxine v placebo; P = .045 for clonidine v placebo). Frequencies of treatment-related adverse effects of nausea (P = .02), constipation (P = .04), and severe appetite loss were higher in the venlafaxine group. Conclusion: Venlafaxine and clonidine are effective treatments in the management of hot flashes in patients with breast cancer. Venlafaxine resulted in a more immediate reduction of hot flash scores when compared with clonidine; however, hot flash scores at week 12 were lower in the clonidine group than in the venlafaxine group. |
Keywords: | Humans Breast Neoplasms Hot Flashes Cyclohexanols Clonidine Analgesics Placebos Treatment Outcome Double-Blind Method Adult Aged Middle Aged Female Venlafaxine Hydrochloride Selective Serotonin Reuptake Inhibitors |
Rights: | © 2011 American Society of Clinical Oncology |
DOI: | 10.1200/JCO.2010.33.1298 |
Published version: | http://dx.doi.org/10.1200/jco.2010.33.1298 |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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