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https://hdl.handle.net/2440/85959
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Type: | Journal article |
Title: | Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery |
Author: | Shi, B. Zhang, H. Dai, S. Du, X. Bi, J. Qiao, S. |
Citation: | Small, 2014; 10(5):871-877 |
Publisher: | Wiley - VCH Verlag GmbH & Co KGaA |
Issue Date: | 2014 |
ISSN: | 1613-6810 1613-6829 |
Statement of Responsibility: | Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi and Shi Zhang Qiao |
Abstract: | A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency. |
Keywords: | Hela Cells Humans Schiff Bases Imidazoles Polymers Chitosan DNA Gene Transfer Techniques Transfection Plasmids Particle Size Cellular Microenvironment |
Rights: | © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/smll.201302430 |
Grant ID: | http://purl.org/au-research/grants/arc/DP130104459 http://purl.org/au-research/grants/arc/DP110102877 |
Published version: | http://dx.doi.org/10.1002/smll.201302430 |
Appears in Collections: | Aurora harvest 7 Chemical Engineering publications |
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