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https://hdl.handle.net/2440/85248
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Type: | Journal article |
Title: | Lysine-appended polydiacetylene scaffolds for human mesenchymal stem cells |
Author: | Haridas, V. Sadanandan, S. Collart-Dutilleul, P. Gronthos, S. Voelcker, N. |
Citation: | Biomacromolecules, 2014; 15(2):582-590 |
Publisher: | American Chemical Society |
Issue Date: | 2014 |
ISSN: | 1525-7797 1526-4602 |
Statement of Responsibility: | V. Haridas, Sandhya Sadanandan, Pierre-Yves Collart-Dutilleul, Stan Gronthos, and Nicolas H. Voelcker |
Abstract: | We report on the self-assembly based fabrication of fibrous polymers for tissue engineering applications. Directed self-assembly followed by polymerization of lysine-appended diacetylenes generated a variety of polymers (P1–P5) with distinct chemical properties. The self-assembly along with the conjugated double and triple bonds and rigid geometry of diacetylene backbone imposed a nanofibrous morphology on the resulting polymers. Chemical properties including wettability of the polymers were tuned by using lysine (Lys) with orthogonal protecting groups (Boc and Fmoc). These Lys-appended polydiacetylene scaffolds were compared in terms of their efficiency toward human mesenchymal stem cells adhesion and spreading. Interestingly, polymer P4 containing Lys Nα-NH2 and Lys Nε-Boc with balanced wettability supported cell adhesion better than the more hydrophobic polymer P2 with Nε-Boc and Nα-Fmoc or more hydrophilic polymer P5 containing free Nε and Nα amino groups. The molecular level control in the fabrication of nanofibrous polymers compared with other existing methods for the generation of fibrous polymers is the hallmark of this work. |
Keywords: | Mesenchymal Stem Cells Humans Polymers Lysine Tissue Engineering Cell Movement Cell Survival Molecular Conformation Particle Size Surface Properties Tissue Scaffolds Polyacetylene Polymer Polyynes |
Rights: | © 2013 American Chemical Society |
DOI: | 10.1021/bm4015655 |
Published version: | http://dx.doi.org/10.1021/bm4015655 |
Appears in Collections: | Aurora harvest 2 Medical Sciences publications |
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