Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/82197
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Type: Journal article
Title: Periprosthetic osteolysis after total hip replacement: molecular pathology and clinical management
Author: Howie, D.
Neale, S.
Haynes, D.
Holubowycz, O.
McGee, M.
Solomon, L.
Callary, S.
Atkins, G.
Findlay, D.
Citation: Inflammopharmacology, 2013; 21(6):389-396
Publisher: Kluwer Academic Publ
Issue Date: 2013
ISSN: 0925-4692
1568-5608
Statement of
Responsibility: 
Donald W. Howie, Susan D. Neale, David R. Haynes, Oksana T. Holubowycz, Margaret A. McGee, Lucian B. Solomon, Stuart A. Callary, Gerald J. Atkins, David M. Findlay
Abstract: Periprosthetic osteolysis is a serious complication of total hip replacement (THR) in the medium to long term. Although often asymptomatic, osteolysis can lead to prosthesis loosening and periprosthetic fracture. These complications cause significant morbidity and require complex revision surgery. Here, we review advances in our understanding of the cell and tissue response to particles produced by wear of the articular and non-articular surfaces of prostheses. We discuss the molecular and cellular regulators of osteoclast formation and bone resorptive activity, a better understanding of which may lead to pharmacological treatments for periprosthetic osteolysis. We describe the development of imaging techniques for the detection and measurement of osteolysis around THR prostheses, which enable improved clinical management of patients, provide a means of evaluating outcomes of non-surgical treatments for periprosthetic osteolysis, and assist in pre-operative planning for revision surgery. Finally, there have been advances in the materials used for bearing surfaces to minimise wear, and we review the literature regarding the performance of these new materials to date.
Keywords: Periprosthetic; Osteolysis; Clinical management; Barrie Vernon-Roberts
Rights: © Springer Basel 2013
RMID: 0020133520
DOI: 10.1007/s10787-013-0192-6
Appears in Collections:Orthopaedics and Trauma publications

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