Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/79044
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Renal cortical pallor - a useful macroscopic marker for metabolic derangements at autopsy |
Author: | Zhou, C. Yool, A. Byard, R. |
Citation: | Journal of Forensic Sciences, 2013; 58(3):693-696 |
Publisher: | Amer Soc Testing Materials |
Issue Date: | 2013 |
ISSN: | 0022-1198 1556-4029 |
Statement of Responsibility: | Chong Zhou, Andrea Yool, and Roger W. Byard |
Abstract: | Renal cortical pallor was studied as a potential marker at autopsy of diabetic ketoacidosis in 23 cases, hyperglycemic nonketotic coma in eight cases, and alcoholic ketoacidosis in five cases (vitreous humor glucose level≥11.1 mM; β-hydroxybutyrate level≥5 mM). Renal cortical pallor was noted on macroscopic examination in 10 of 23 cases of lethal diabetic ketoacidosis (43.5%), three of eight cases of fatal hyperglycemic nonketotic coma (37.5%), and in two of five cases of alcoholic ketoacidosis (40%). Histologic examination revealed basal vacuolization of renal tubular epithelial cells in 12 cases, Armanni-Ebstein lesions in 10, and osmotic nephrosis in three. Although renal cortical pallor did not appear to be a particularly sensitive marker for hyperglycemia or ketoacidosis, and did not correlate with the severity of these parameters, it may still represent a useful macroscopic marker for underlying metabolic conditions at autopsy and should therefore prompt measurement of vitreous humor glucose and β-hydroxybutyrate levels. |
Keywords: | forensic science renal cortical pallor ketoacidosis diabetes mellitus alcoholism hyperglycemia epithelial vacuolization Armanni–Ebstein |
Rights: | © 2013 American Academy of Forensic Sciences |
DOI: | 10.1111/1556-4029.12102 |
Published version: | http://dx.doi.org/10.1111/1556-4029.12102 |
Appears in Collections: | Aurora harvest 4 Pathology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.