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https://hdl.handle.net/2440/78046
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Type: | Journal article |
Title: | Stromal miR-320 keeps an oncogenic secretome in check |
Author: | Khew-Goodall, Y. Goodall, G. |
Citation: | Nature Cell Biology, 2012; 14(2):124-125 |
Publisher: | Nature Publishing Group |
Issue Date: | 2012 |
ISSN: | 1465-7392 1476-4679 |
Statement of Responsibility: | Yeesim Khew-Goodall and Gregory J. Goodall |
Abstract: | Cancer-associated fibroblasts contribute to malignancy by expressing secreted pro-tumorigenic molecules. The microRNA miR-320 is now shown to be a crucial component of a PTEN-controlled tumour-suppressive axis in stromal fibroblasts. Loss of PTEN and miR-320 induces an oncogenic secretome that reprogrammes the tumour microenvironment to promote invasion and angiogenesis. |
Keywords: | Animals Humans MicroRNAs Gene Expression Profiling Gene Expression Regulation, Neoplastic Female PTEN Phosphohydrolase Tumor Microenvironment |
Rights: | © 2012 Macmillan Publishers Limited. All rights reserved. |
DOI: | 10.1038/ncb2431 |
Published version: | http://dx.doi.org/10.1038/ncb2431 |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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